We drove our 2015 suby loaded to the gill from CA to OH when we moved last January.. That was about 4 days and 2800 miles with some visits along the way. The ride was pretty decent considering the amount of driving. Snow tires were a bit noisy, but we just turned up the stereo..
Since our move, we've driven from OH to Virginia Beach a few times (about 600 mi each way). It's an all day drive, but fairly comfortable.